*,:before,:after{box-sizing:border-box;margin:0;padding:0}body{color:#2c3e50;background:#ecf0f1;min-height:100vh;font-family:-apple-system,BlinkMacSystemFont,Segoe UI,Roboto,sans-serif}a{color:#18bc9c;text-decoration:none}a:hover{text-decoration:underline}#root{text-align:left;border:none;width:auto;display:block}.container{width:100%}.app-shell{flex-direction:column;min-height:100vh;display:flex}.app-header{color:#fff;background:#2c3e50;border-bottom:4px solid #18bc9c;align-items:center;gap:.85rem;padding:.85rem 1.25rem;display:flex}.app-title{letter-spacing:.02em;font-size:1.15rem;font-weight:600}.sidebar-toggle{color:#fff;cursor:pointer;background:0 0;border:1px solid #ffffff40;border-radius:4px;padding:.3rem .65rem;font-size:1.1rem;font-weight:400;line-height:1}.sidebar-toggle:hover{background:#ffffff1a}.app-body{flex:1;min-height:0;display:flex}.sidebar{background:#fff;border-right:1px solid #dfe6e9;flex-shrink:0;width:240px;padding:1rem .75rem}.nav-list{margin:0;padding:0;list-style:none}.nav-list li{margin:0}.nav-item{color:#2c3e50;background:#fff;border:1px solid #dfe6e9;border-bottom:none;padding:.65rem .85rem;font-size:.92rem;text-decoration:none;transition:background .12s;display:block}.nav-list li:last-child .nav-item{border-bottom:1px solid #dfe6e9}.nav-list li:first-child .nav-item{border-top-left-radius:4px;border-top-right-radius:4px}.nav-list li:last-child .nav-item{border-bottom-right-radius:4px;border-bottom-left-radius:4px}.nav-item:hover{background:#f8f9fa;text-decoration:none}.nav-item.active{color:#fff;background:#18bc9c;border-color:#18bc9c}.sidebar-search{margin-top:1rem;padding:0 .25rem}.sidebar-search hr{border:none;border-top:1px solid #dfe6e9;margin:0 0 .85rem}.search-label{color:#2c3e50;margin-bottom:.4rem;font-size:.85rem;font-weight:600;display:block}.app-main{background:#ecf0f1;flex:1;min-width:0;overflow-x:hidden}h1{color:#2c3e50;margin-bottom:.25rem;font-size:1.7rem;font-weight:500}h2{color:#2c3e50;margin-bottom:.75rem;font-size:1.25rem;font-weight:500}h3{color:#2c3e50;margin-bottom:.5rem;font-size:1.15rem;font-weight:600}h4{color:#2c3e50;margin-bottom:.5rem;font-size:1.05rem;font-weight:600}.page{padding:1.5rem 1.25rem}.card{background:#fff;border-radius:4px;margin-bottom:1.25rem;padding:1.25rem;box-shadow:0 1px 4px #0000000f}.controls{flex-wrap:wrap;align-items:center;gap:1rem;margin-bottom:1.25rem;display:flex}select,input{background:#fff;border:1px solid #ced4da;border-radius:4px;padding:.4rem .7rem;font-family:inherit;font-size:.9rem}select:focus,input:focus{border-color:#18bc9c;outline:2px solid #18bc9c}button{cursor:pointer;border:none;border-radius:4px;padding:.4rem .9rem;font-family:inherit;font-size:.9rem;font-weight:500}.btn-primary{color:#fff;background:#2c3e50}.btn-primary:hover{background:#1a252f}.btn-secondary{color:#fff;background:#95a5a6}.btn-secondary:hover{background:#798d8f}.btn-success{color:#fff;background:#18bc9c}.btn-success:hover{background:#15a589}.btn-warning{color:#fff;background:#f39c12}.btn-warning:hover{background:#d68910}.btn-sm{padding:.25rem .6rem;font-size:.8rem}button:disabled{opacity:.5;cursor:not-allowed}.wake-banner{background:#fff3cd;border:1px solid #f39c12;border-radius:4px;align-items:center;gap:1rem;margin-bottom:1.25rem;padding:1rem;display:flex}table{border-collapse:collapse;width:100%;font-size:.88rem}th{text-align:left;color:#2c3e50;background:#ecf0f1;border-bottom:2px solid #dfe6e9;padding:.5rem .75rem;font-weight:600}td{border-bottom:1px solid #ecf0f1;padding:.45rem .75rem}table.striped tbody tr:nth-child(2n) td{background:#f3f6f8}tr:hover td{background:#e9eef3!important}.gene-table-scroll{max-height:420px;margin-top:.75rem;overflow:auto}.gene-table-scroll table{border-collapse:separate;border-spacing:0}.gene-table-scroll th{background:#ecf0f1}.gene-table-scroll thead tr:nth-child(2) th{z-index:2;position:sticky;top:0;box-shadow:inset 0 -2px #dfe6e9}.gene-table-scroll thead tr:nth-child(2) th[style*=background]{background:#ecf0f1!important}.search-wrap{display:inline-block;position:relative}.suggestions{z-index:100;background:#fff;border:1px solid #ced4da;border-radius:0 0 4px 4px;max-height:220px;position:absolute;top:100%;left:0;right:0;overflow-y:auto;box-shadow:0 4px 12px #0000001a}.suggestions li{cursor:pointer;padding:.4rem .75rem;font-size:.88rem;list-style:none}.suggestions li:hover,.suggestions li.active{background:#ecf0f1}.spinner{border:3px solid #dfe6e9;border-top-color:#18bc9c;border-radius:50%;width:2rem;height:2rem;margin:2rem auto;animation:.7s linear infinite spin}@keyframes spin{to{transform:rotate(360deg)}}.structure-img{border-radius:4px;max-width:100%}.gene-header{align-items:baseline;gap:.75rem;margin-bottom:.25rem;display:flex}.error{color:#e74c3c;padding:.5rem 0;font-size:.9rem}.empty-state{text-align:center;color:#888;flex-direction:column;justify-content:center;align-items:center;height:60vh;display:flex}.modal-backdrop{z-index:1000;background:#00000073;justify-content:center;align-items:center;display:flex;position:fixed;inset:0}.modal{background:#fff;border-radius:4px;min-width:320px;max-width:500px;padding:1.5rem;box-shadow:0 10px 30px #0000004d}